objective(s): anti-epileptic drugs (aeds) have the potential to affect fetal development throughout pregnancy. considering the broad therapeutic indications of pregabalin (pgb), its potential teratogenic effects and the levels of homocysteine have been studied.   materials and methods: timed-pregnant mice received one of three doses of pgb (20, 40 or 80 mg/kg/day) or the vehicle control during ...

perfluorooctanesulfonate (pfos) is a widely spread environmental contaminant. it accumulates in the brain and has potential neurotoxin effects. due to chemical properties, pfos shows persistency in the environment and therefore has potential hazardous effect. the risk of possible intra uterine exposure to pfos poses a health concern for developmental effects. the goal of this study was survey o...

although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. in recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (sc) to mice. decreased fertili...